InSolution Casein Kinase II Inhibitor III; TBCA

Biochem/physiol Actions

Reversible: yes

Primary TargetCKII

Cell permeable: yes

General description

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (>Cat. No. 218697 and >Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pagano, M.A., et al. 2006. Chembiochem,8, 129.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Physical form

A 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)